Endocrine Abstracts

Introduction: Mitotane is an adrenolytic drug that is used as an adjuvant to treat adrenocortical carcinoma, The side effects of lysodren are numerous, but some of them are less known. We report a case of ovarian cyst in a woman of childbearing age. It is a 26 years old patient treated with Lysodren® for a locoregional recurrence of an adrenal cacinoma stage II of the ENSAT. After 9 months of treatment, the patient presented an amenorrhea, with the appearance of a large o...

Introduction: Oncocytomas of adrenal glands are extremely rare and usually present as incidentally detected masses. The aim of this presentation is to report tow cases of a virilizing androgen-secreting adrenal oncocytoma.Case description: Case 1: A 27-year-old female was admitted to our clinic with a 116 mm left adrenal incidentaloma. The patient’s main symptom was hirsutism. Upon investigation, elevated values of testosterone, and DHEA-S were foun...

Central diabetes insipidus (CDI) is rare in children and has a wide variety of causes. In children, the majority of central DI is acquired, but 30 to 50% is considered idiopathic. However, the natural history of isolated idiopathic central ID is unpredictable and germinoma should always be considered during the first 3 years of follow-up.Case report: We report the observation of a 16 year old patient, in whom the diagnosis of idiopathic central diabetes ...

Introduction: Adrenal oncocytomas are rare and usually present as incidentally detected masses. The aim of this study is to evaluate the clinical characteristics of a series of patients with adrenal oncocytoma.Material and Methods: we retrospectively collated all patients admitted to Bologhine Hospital between 2010 and 2020 for adrenal masses and who underwent surgery and a diagnosis of adrenal oncocytoma at the anathomo-pathological study (n=07...

Introduction: The diagnosis of primary hyperaldosteronism (PAH) is based on the realization of the renin aldosterone ratio (RAR). The presence of renal insufficiency (RI) in a hypertensive patient complicates this diagnosis by affecting various biological assays.Observation: We report the case of 25-year-old female, with a personal history of primary hypothyroidism, hypertension diagnosed at age 21 and severe renal insufficiency developed during a pregna...

Introduction: Spindle cell oncocytoma (SCO) of the pituitary gland is a rare thyroid transcription factor 1 (TTF-1)-positive pituitary neoplasm.Observation: We report the case of a 42-year-old man, with a personal history of type 2 diabetes, consulting for intense headaches and vomiting. The visual field shows an amputation of the left temporal hemifield and the MRI shows a pituitary adenoma with suprasellar development, initially measuring 22×28&#2...

Introduction: Thyroid tuberculosis is a rare entity even in countries like Algeria where tuberculosis is endemic.Observation: We report the case of a 40-year-old woman, with a history of hypertension and severe renal failure, consulting for recent cervical swelling evolving in a context of asthenia, nocturnal fever and weight loss. The clinical examination found a compressive goitre. The biological assessment objectified a primary hypothyroidism and an i...

Introduction: Several treatments may be proposed against neuroendocrine tumors such as targeted therapies (Tyrosine kinase inhibitors: TKI) and somatostatin agonist. Since the first use of TKI in the oncological field, several studies have shown endocrine side effects type dysthyroidie. Several complex pathophysiological mechanisms and variable from one patient to another have been evoked ranging from a simple thyroiditis to complex autoimmune phenomena (cases of Basedow revea...

IntroductionThe diagnosis of primary hyperparathyroidism (PHP) is essentially biological. Current imaging techniques (ultrasound and scintigraphy) make it possible to locate an adenoma in the majority of cases. The objective of this study is to clarify the place of imaging in the topographic diagnosis of hyperparathyroidism.Patients and methodsThis is a retrospective study including 40 patients with PHP who h...

IntroductionOsteoporosis has generally been considered a female disease; this may explain why this pathology has focused less attention on men. While osteoporosis has been underestimated and poorly treated in female patients, the situation is even worse in male patients, despite the fact that up to one third of hip fractures are suffered by men.GoalTo assess the characteristics and risk factors associated wit...